In several Latin American countries neopopulist, antipolitical actors have become influential. They have posed serious political threats to the institutional perspectives of democratic consolidation proposing dubious alternatives and policies which eschew the institutional problems of unstable democracies based on party systems and state structures with great legitimacy and representativity problems. This paper is an attempt to discuss from a comparative standpoint three different cases of neopopulist antipolitics. It focuses on their distinctive character in Peru, Brazil and Bolivia regarding their origins, and discourse; on the specific political contexts and institutional mechanism which, on the one hand, encouraged the rise to power of Fujimori and Collor de Melo, and, on the other hand, constrained neopopulist actors in Bolivia; and finally on the different impact of antipolitics on democracy in these countries.